Much brighter and more hydrated skin: the results after using a serum with PDRN for two months

Posted on 8 September 2026

It has been used for a long time in regenerative medicine due to its healing power and how well it works in tissue repair, although it is now that it has become more fashionable because it has been included as an ingredient in some cosmetic products. I'm talking to you about PDRN, a Korean ingredient extracted from salmon sperm, which imitates human DNA to accelerate skin regeneration.

This active ingredient promises to regenerate, hydrate, calm, illuminate and rejuvenate. I just turned 40 and I want it all. The bad news is that the greatest benefits are obtained with PDRN injections, but letting a needle pierce my skin to look prettier for the moment is not something that attracts my attention (nor that I can afford). The good thing is that this ingredient is already in some serums. And since I'm a bit catacald as they would say in my father's town, a few months ago I included one with PDRN to complement my retinol routine. The serum chosen is the PDRN Pink Peptide serum, from Medicube. The best-selling serum on Amazon and with a not crazy price, 14.95 euros.

We tried the PDRN Pink Peptide serum, from Medicube

Although I hardly have any wrinkles, it is becoming more and more difficult for me to maintain the luminosity of my skin. Until a few years ago, using vitamin C was enough, but for some time now I have noticed that it is a little more difficult for my skin to avoid that sallow tone that it tends to, and one of the effects of PDRN that I have noticed is that it gives me that extra luminosity that my skin asks for. In terms of wrinkles, I don't notice much but in terms of hydration, yes.

Since I use retinol in my routine, this serum is more of a complement than at the moment, it has replaced the vitamin C I was using. After two months, I notice my skin has a healthy tone that my old serum no longer achieved, and throughout the summer I have stopped using the Nyx makeup base and the Mercadona illuminating serum and my skin doesn't look bad at all.

Another of the promised benefits is reducing spots, another of my great enemies, and the truth is that despite it being summer, I have not noticed that they have increased or new ones appeared, and I have even managed to keep melasma at bay.

Ingredients and benefits of PDRN Pink Peptide serum, from Medicube

This serum contains salmon PDRN, an ingredient that seeks to stimulate cell regeneration, improve skin elasticity, soften expression lines, reduce spots and restore firmness. In addition to PDRN, Medicube serum contains salmon collagen and peptides that improve texture and strengthen the skin barrier. It has niacinamide and turmeric root extract that provide luminosity and combat hyperpigmentation, and also hyaluronic acid for deep hydration.

How to use PDRN Pink Peptide serum, from Medicube

Like any serum, it must be applied to clean skin. My routine is always the same. Whether makeup or not, I cleanse my skin with my trusted cleanser, CeraVe Foaming Cleanser. Once clean, I pat dry with a towel and apply the serum. Chimpún. Nothing else.

I am reducing the number of products I apply each day, and one of the products I have removed is night cream. I don't usually, unless my skin notices very very dry, use any moisturizer at night, but I do use two different serums to maintain hydration. One day I put on the PDRN one and another, one with hyaluronic acid. The third day, it's retinol. My skin has never been so hydrated and it is because of the combination of all three things.

There are no magic products, but there are combinations that work. In my case, that combination includes Medicube's PDRN Pink Peptide serum and I don't think it will disappear from my makeup bag anytime soon.

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Olivia Thompson
Olivia Thompson
I’m Olivia Thompson, born and raised in Wellington, New Zealand. As a lifestyle and travel writer at Latitude Magazine, I’m passionate about uncovering stories that connect people with new experiences and perspectives. My goal is to inspire readers to see everyday life – and the world – with fresh eyes.

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